The Protective Effects of Beta Glucan Against Experimental Renal Ischemia Reperfusion Injury

Aim: This study aims to investigate the possible protective effects of beta-glucan against oxidative stress caused by ischemia and reperfusion injury in kidney tissue.Methods: In study, 30 male Wistar albino rats weighing 300-350g were used (n=10). Rats randomly grouped into three groups Sham control, group (IR), + beta glucan (IR BG). had left nephrectomy, right taken for histopathologic biochemical examination. After nephrectomy IR group, procedure was applied 45 minutes via nontraumatic microvascular clamp, then 60 kidney. IR+BG administered 100 mg/kg gastric gavage 10 days. Reperfusion after under anesthesia.Results: As a result examination MDA values showed significant increase compared (p<0,05). there decrease Tissue MPO whereas not decrease. Also, difference tissue catalase levels. GSH found Less damage has been revealed examination.Conclusion: All these data show that may have an antioxidant effect on renal injury.